Deoxyxylothymidine 3'-O-phosphorothioates: Synthesis, stereochemistry and stereocontrolled incorporation into oligothymidylates

DOI: 10.1016/S0960-894X(97)10040-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2651 - 2656 (1997)

Update date:2022-09-26

Topics:

Authors:

Yang, Xian-Bin

Misiura, Konrad

Sochacki, Marek

Stec, Wojciech J.

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Article abstract of DOI:10.1016/S0960-894X(97)10040-3

New reagent, 5'-O-DMT-xylothymidine 3'-O-(2-thio-4,4-spiropentamethylene-1,3,2-oxathiaphospholane) and its separated diastereomers can be used for stereocontrolled incorporation of xylothymidine 3'-O-phosphorothioate of predetermined sense of P-chirality into desired oligonucleotide constructs.

Full text of DOI:10.1016/S0960-894X(97)10040-3

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