Deoxyxylothymidine 3'-O-phosphorothioates: Synthesis, stereochemistry and stereocontrolled incorporation into oligothymidylates

DOI: 10.1016/S0960-894X(97)10040-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2651 - 2656 (1997)

Update date:2022-09-26

Topics:

Authors:

Yang, Xian-Bin

Misiura, Konrad

Sochacki, Marek

Stec, Wojciech J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10040-3

New reagent, 5'-O-DMT-xylothymidine 3'-O-(2-thio-4,4-spiropentamethylene-1,3,2-oxathiaphospholane) and its separated diastereomers can be used for stereocontrolled incorporation of xylothymidine 3'-O-phosphorothioate of predetermined sense of P-chirality into desired oligonucleotide constructs.

Full text of DOI:10.1016/S0960-894X(97)10040-3

Products guided by the article

Product name:1-[(2R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-thioxo-3-oxa-1-thia-2λ⁵-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:198637-82-0

R&D Labs maybe for 198637-82-0

Shanghai Synmedia Chemical Co., Ltd

Contact:+86-21-38681880

Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Zibo Jujin Chemical Industry Co., Ltd.（Dongming Jujin Chemical Industry Co., Ltd. ）

Contact:+86-533-2975022

Address:No.99 Shanquan Road, Zhangdian District
Shandong Wanda Organosilicon New Material Co., Ltd

Contact:+86-21-54177116;54302881

Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
Oren Hydrocarbons (Qingdao) Co., Ltd.

Contact:+86-532-68607667-801

Address:Room 3 # 302, No.9 Qingyun Road, Qingdao, China

Relevant to this article

Redox-responsive xanthene-coumarin-chlorambucil-based FRET-guided theranostics for "activatable" combination therapy with real-time monitoring

Doi:10.1039/c7cc03241b
(2017)
Towards long-living metathesis catalysts by tuning the N-heterocyclic carbene (NHC) ligand on trifluoroacetamide-activated boomerang ru complexes

Doi:10.1002/ejoc.200900407
(2009)
Synthesis of New 1,3,4-Thiadiazole Derivatives Containing of Morpholine Ring

Doi:10.14233/ajchem.2013.13227
(2013)
Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential

Doi:10.1016/j.bmcl.2004.07.001
(2004)
Synthesis of lysophosphatidylserine with 19:4 acyl group, as a novel sodium-potassium ATPase inhibitor, in relation to DLIS-2, an endogenous digoxin-like substance

Doi:10.1016/S0040-4039(00)94492-7
(1990)
Diastereodivergency in the reactions of 3-metallated-2-methylbutanamide

Doi:10.1016/S0040-4020(97)10292-7
(1998)

Article Doi