Synthesis of optically active diols bearing a long chain via enzymatic hydrolysis of cyclic carbonates

Article abstract of DOI:10.1246/cl.1997.1151

PPL catalyzes the hydrolysis of racemic five-membered cyclic carbonates bearing a long chain with high enantioselectivity. Optically pure (S)-(+)-8-hydroxyhexadecanoic acid is effectively synthesized starting from (R)-4-(7-benzyloxy)heptyl-1,3-dioxolan-2-one and (S)-9-benzyloxynonane-1,2-diol, which are prepared via an enzymatic reaction.