Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements

DOI: 10.1055/s-1997-1003

Source and publish data:

Synlett p. 1287 - 1290 (1997)

Update date:2022-08-04

Topics:

Authors:

De Mesmaeker, Alain

Lebreton, Jacques

Jouanno, Chantal

Fritsch, Valérie

Wolf, Romain M.

Wendeborn, Sebastian

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1997-1003

The amide backbone modification C3′-CH₂-CONH-C5′ has been further modified by introducing a methyl at C5′, either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. A

Full text of DOI:10.1055/s-1997-1003

Products guided by the article

Product name:Methanesulfonic acid 1-[(2S,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl ester

Cas No:199458-04-3

R&D Labs maybe for 199458-04-3

TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)

Contact:22-58516360

Address:tianjin
SHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD

Contact:86-21-60560171

Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Shanghai Send Pharmaceutical Technology Co., Ltd.

website:http://www.shsendpharma.com

Contact:021-58088081, +8613585868794

Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Shaanxi Sinuote Biotech Co.,Ltd

Contact:+86-29-68859685

Address:No 18,Taiyuan Road ,Xi'an city ,China

Relevant to this article

Dual recognition of double-stranded DNA by 2'-aminoethoxy-modified oligonucleotides

Doi:10.1002/(SICI)1521-3773(19980518)37:9<1288::AID-ANIE1288>3.0.CO;2-U
(1998)
Synthesis of 2'-O,4'-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed c₃-endo sugar puckering

Doi:10.1016/S0040-4039(97)10322-7
(1997)
Remote control of dieis-alder additions. Enantioselective synthesis of (2r). 1,2,3,4-tetrahydro-2-hydroxy-5,8-dimethoxynaphthalen-2-yl methyl ketone (Wong's anthracycline intermediate) from furfural

Doi:10.1016/S0957-4166(97)00433-3
(1997)
Doi:10.1139/v68-463
(1968)
Poly{[4-(hydroxy)(tosyloxy)iodo]styrene}-promoted aromatisation of Hantzsch 1,4-dihydropyridines

Doi:10.3184/030823407X262454
(2007)
In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor

Doi:10.1002/ejoc.201900471
(2019)

Article Doi