Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements

DOI: 10.1055/s-1997-1003

Source and publish data:

Synlett p. 1287 - 1290 (1997)

Update date:2022-08-04

Topics:

Authors:

De Mesmaeker, Alain

Lebreton, Jacques

Jouanno, Chantal

Fritsch, Valérie

Wolf, Romain M.

Wendeborn, Sebastian

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Article abstract of DOI:10.1055/s-1997-1003

The amide backbone modification C3′-CH₂-CONH-C5′ has been further modified by introducing a methyl at C5′, either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. A

Full text of DOI:10.1055/s-1997-1003

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