Pteridine nucleosides - New versatile building blocks in oligonucleotide synthesis

Article abstract of DOI:10.1080/07328319708006188

Chemical syntheses of 1-(2-deoxy-β-D-ribofuranosyl)lumazines and isoptefins as well as 8-(2-deoxy-β-D-ribofuranosyl)-4-amino-7(8H)pteridones and -isoxantho-pterins have been developed to make the structural analogs of the naturally occurring 2'-deoxyribonucleosides in the pteridine series available. The corresponding phosphoramidites have been used in machine- aided solid-support syntheses leading to new types of fluorescence labeled oligonucleotides. The effects of the various fluorophors on duplex formation and as labels for enzyme reactions is demonstrated.

Full text of DOI:10.1080/07328319708006188

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Nucleosides and Nucleotides
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Pteridine Nucleosides—New Versatile
Building Blocks in Oligonucleotide
Synthesis
Ramamurthy Charubala a , Juris Maurinsh a , Angelika Rösler a
Manuel Melguizo a , Oliver Jungmann a , Margarete Gottlieb a
Jörg Lehbauer a , Mary Hawkins b & Wolfgang Pfleiderer a
,
,
a Fakultät für Chemie , Universität Konstanz , Postfach 5560,
D-78434, Konstanz
b National Institutes of Health , Bethesda, USA
Published online: 16 Aug 2006.
To cite this article: Ramamurthy Charubala , Juris Maurinsh , Angelika Rösler , Manuel Melguizo ,
Oliver Jungmann , Margarete Gottlieb , Jörg Lehbauer , Mary Hawkins & Wolfgang Pfleiderer
(1997) Pteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis,
Nucleosides and Nucleotides, 16:7-9, 1369-1378, DOI: 10.1080/07328319708006188
To link to this article: http://dx.doi.org/10.1080/07328319708006188
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