Archiv der Pharmazie p. 327 - 332 (1997)
Update date:2022-08-02
Topics:
Aboul-Fadl, Tarek
El-Shorbagi, Abdel-Nasser
3,5-Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives; 4a-g were prepared and found to be a promising prodrug approach for peptide drugs. The pH profile for their degradation in aqueous buffer solutions was determined using HPLC technique and accounted for, in terms of specific base-catalyzed reactions. All of the compounds however, showed high acid-stability. Enzymatic (human serum) hydrolysis of the different derivatives offered an advantageous range of t( 1/4 )'s, the property that permits controlling onset and duration of actions of drugs.
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Doi:10.1111/j.2042-7158.1965.tb07674.x
(1965)Doi:10.1016/S0040-4039(97)10357-4
(1997)Doi:10.1007/s10593-020-02770-w
(2020)Doi:10.1007/BF02291807
(1997)Doi:10.1016/S0040-4039(01)98912-9
(1968)Doi:10.1002/hlca.19680510625
(1968)
