Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

DOI: 10.1016/S0040-4039(99)00864-3

Source and publish data:

Tetrahedron Letters p. 4943 - 4946 (1999)

Update date:2022-09-26

Topics:

Authors:

Wittman, Mark D.

Alstadt, Thomas J.

Kadow, John F.

Vyas, Dolatrai M.

Johnson, Kathy

Fairchild, Craig

Long, Byron

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Article abstract of DOI:10.1016/S0040-4039(99)00864-3

The synthetic transposition of the 7-hydroxyl group of paclitaxel to the 6-position is described. The route presented prepares both the 6-α- and β- isomers stereospecifically. The key step of this transposition involves the stereoselective reduction of th

Full text of DOI:10.1016/S0040-4039(99)00864-3

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