
Tetrahedron Letters p. 4943 - 4946 (1999)
Update date:2022-09-26
Topics:
Wittman, Mark D.
Alstadt, Thomas J.
Kadow, John F.
Vyas, Dolatrai M.
Johnson, Kathy
Fairchild, Craig
Long, Byron
The synthetic transposition of the 7-hydroxyl group of paclitaxel to the 6-position is described. The route presented prepares both the 6-α- and β- isomers stereospecifically. The key step of this transposition involves the stereoselective reduction of th
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