A Simple Approach to β-Amino Acids by Acylation of Arenes with N-Acyl Aspartic Anhydrides

Article abstract of DOI:10.1055/s-1997-1007

Friedel-Crafts acylation of arenes (benzene, toluene, o-xylene) with N-protected (Bz, Ac, Ac-Bn, Ts, Tfac, N,N-Pht) aspartic anhydrides (1a-1f) resulted in mixtures of α- and β-amino acids. The β/ α-selectivity could be optimized for alkylated arenes (toluene, xylene) and the N-Ac, N-Bn protected 1c.