Journal of Heterocyclic Chemistry p. 1493 - 1496 (1994)
Update date:2022-08-03
Topics:
Bolos
Gubert
Anglada
Perez
Sacristan
Ortiz
The synthesis of the novel amino acid 6-(hydroxymethyl)-2-piperidinecarboxylic acid (1a) and its ethyl ester 1b is reported. In the hydrogenation of 6-(hydroxymethyl)pyridine-2-carboxylates, hydrogenolysis of the alcohol group appeared as an unusual side reaction. Optimization of the reaction conditions allowed us to minimize hydrogenolysis and afforded pure 1.
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