A One-Step Synthesis of Alkyl 2-Oxo-3-alkenoates from Alkenyl Grignard Reagents and Dialkyl Oxalates

Article abstract of DOI:10.1055/s-1988-27642

The reaction of alkenyl Grignard reagents with dialkyl oxalates at -80 deg C in an ether/tetrahydrofuran mixture (1:1) leads to the formation of the corresponding alkyl 2-oxo-3-alkenoates in high yields.Thus a mild and convenient one-step synthesis of 3-isopropenyl-substituted 2-oxoesters is described.