The synthesis of bisanthraquinone derivatives as DNA bisintercalating agents

Article abstract of DOI:10.1016/S0040-4020(97)10196-X

The linked bisanthraquinone derivatives 4a-c were synthesized as DNA bisintercalating agents. Starting from the aldehyde 7, the linking chain was introduced via a Grignard reaction to afford the ethers 9a-c. Subsequent anodic oxidation of these products, followed by annelation with the anion of phthalide 5 afforded the linked anthraquinones 12. The target compounds were then obtained by selective esterification with the acid 14, followed by deprotection with anhydrous hydrogen chloride.