Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

Article abstract of DOI:10.1016/S0040-4039(97)10367-7

Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)4/2i-PrMgCl reagent, which, in turn, react with aldehydes regio- and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields.