Cyclo-saligenyl-2',3'-dideoxy-2',3' didehydroythymidinemonophosphate (cyclosal-d4TMP) - A new pro-nucleotide approach

Article abstract of DOI:10.1080/07328319708006176

The synthesis of cycloSal-d4TMP 3a-g as new pro-nucleotide approach for d4TMP 2 is described. Phosphotriesters 3 release the d4TMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSa1-phosphotriesters 3 exhibited high biological activity against HIV-1/HIV-2 in CEM cells which was completely retained in CEM TK- cells.

Full text of DOI:10.1080/07328319708006176

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Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-
didehydroythymidinemonophosphate
(cycloSal-d4TMP) — A New Pro-
Nucleotide Approach
Chris Meier a , Martina Lorey a , Eric De Clercq b & Jan Balzarini
b
a Institute of Organic Chemistry, Johann Wolfgang Goethe-
University , Marie-Curie-Str.11, D-60439, Frankfurt am Main,
Germany
b Rega Institute for Medical Research, Katholieke Universiteit
Leuven , B-3000, Leuven, Belgium
Published online: 16 Aug 2006.
To cite this article: Chris Meier , Martina Lorey , Eric De Clercq & Jan Balzarini (1997)
Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP)
— A New Pro-Nucleotide Approach, Nucleosides and Nucleotides, 16:7-9, 1303-1306, DOI:
10.1080/07328319708006176
To link to this article: http://dx.doi.org/10.1080/07328319708006176
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