Bioorganic and Medicinal Chemistry Letters p. 1657 - 1662 (1996)
Update date:2022-08-03
Topics:
Bolon, Pascal J.
Wang, Peiyuan
Chu, Chung K.
Gosselin, Gilles
Boudou, Valerie
Pierra, Claire
Mathe, Christophe
Imbach, Jean-Louis
Faraj, Abdesselem
El Alaoui, M. Abdelaziz
Sommadossi, Jean-Pierre
Balakrishna Pai
Zhu, Yong-Lian
Lin, Ju-Sheng
Cheng, Yung-Chi
Schinazi, Raymond F.
β-L-2',3'-Dideoxyadenosine, β-L-2',3'-didehydro-2',3'-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β-L-2',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-HIV (EC50 0.38 μM in PBM cells) and anti-HBV activity (EC50 1.2 μM).
View Morewebsite:http://www.sdowchem.com
Contact:86-135-2193 7483
Address:8-106 taiyue building
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Contact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Shanghai WinTide BioTechnology Co.,Ltd
Contact:86-21-37100630
Address:No. 908 Yunhe Road, Fengxian district, Shanghai
Doi:10.1016/S0040-4020(97)10234-4
(1997)Doi:10.1016/S0040-4020(01)01128-0
(2002)Doi:10.1021/ic970421q
(1998)Doi:10.1039/a808039i
(1999)Doi:10.1021/acs.joc.5b00455
(2015)Doi:10.1021/jo01269a078
(1968)