Anti-human immunodeficiency and anti-hepatitis B virus activities of β-L-2',3'-dideoxy purine nucleosides

Article abstract of DOI:10.1016/0960-894X(96)00293-4

β-L-2',3'-Dideoxyadenosine, β-L-2',3'-didehydro-2',3'-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that β-L-2',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-HIV (EC₅₀ 0.38 μM in PBM cells) and anti-HBV activity (EC₅₀ 1.2 μM).