Design, synthesis and quantitative structure-activity relationship study of N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl)guanidine derivatives as potent Na/H exchange inhibitors

DOI: 10.1248/cpb.45.1975

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1975 - 1983 (1997)

Update date:2022-07-29

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Authors:

Yamamoto, Takeshi

Hori, Manabu

Watanabe, Ikuo

Tsutsui, Hisayoshi

Harada, Kengo

Ikeda, Shoji

Maruo, Joji

Morita, Tominori

Ohtaka, Hiroshi

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Article abstract of DOI:10.1248/cpb.45.1975

Inhibition of the Na/H exchanger is a promising approach for treating ischemia-reperfusion injury, but no clinical agent is yet available. Recently, we established the structural requirements for potent inhibitors of the Na/H exchanger. In the present wor

Full text of DOI:10.1248/cpb.45.1975

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