Design, synthesis and quantitative structure-activity relationship study of N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl)guanidine derivatives as potent Na/H exchange inhibitors

DOI: 10.1248/cpb.45.1975

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1975 - 1983 (1997)

Update date:2022-07-29

Topics:

Authors:

Yamamoto, Takeshi

Hori, Manabu

Watanabe, Ikuo

Tsutsui, Hisayoshi

Harada, Kengo

Ikeda, Shoji

Maruo, Joji

Morita, Tominori

Ohtaka, Hiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1975

Inhibition of the Na/H exchanger is a promising approach for treating ischemia-reperfusion injury, but no clinical agent is yet available. Recently, we established the structural requirements for potent inhibitors of the Na/H exchanger. In the present wor

Full text of DOI:10.1248/cpb.45.1975

NII-Electronic Library Service

Products guided by the article

Product name:3-Oxo-2-phenyl-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

Cas No:201294-18-0

R&D Labs maybe for 201294-18-0

Taizhou volsen chemical Co., Ltd

website:http://www.volsenchem.com

Contact:+86-576-88869393

Address:Jiaojiang District, Taizhou, Zhejiang, China.
Shifang Taifeng New Flame Retardant Co., Ltd

Contact:02884721008

Address:tingjiang industrial park, hefeng town
Tocopharm Co., Ltd.

Contact:+86-021-6989-5597

Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
SICHUAN TONGSHENG AMINOACID CO.LTD

website:http://www.aminoacid.cc

Contact:86-838-2274206/2850606

Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Hangzhou Ocean Chemical Co., Ltd.

website:http://www.hzoceanchem.com

Contact:+86-571-88025872, 28272092, 28272096

Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China

Relevant to this article

An efficient synthesis of (±)-6,7-dimethoxy-1-oxo-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinoline

Doi:10.1081/SCC-100000530
(2001)
Doi:10.1021/jo01266a071
(1968)
EXCITED-STATE DIPOLE MOMENT AND SOLVATOCHROMISM OF HIGHLY FLUORESCENT ROD-SHAPED BICHROMOPHORIC MOLECULES.

Doi:10.1021/ja00334a011
(1984)
Doi:10.1007/BF00755304
()
(1-Ethoxyvinyl)lithium in the total synthesis of thymine polyoxin C and uracil polyoxin C

Doi:10.1248/cpb.46.1034
(1998)
Mechanistic Studies on Cyclopalladation of the Solvated Palladium (II) Complexes with N-Benzyl Triamine Ligands in Various Solvents. Crystal Structures of [Pd(Sol)(Bn₂Medptn)](BF₄)₂ (Sol = Acetonitrile and N, N-Dimethylformamide; Bn₂Medptn = N, N′-Dibenzyl-4-methyl-4-azaheptane-1,7-diamine) and [Pd(H_-1Bn₂Medptn-C, N

Doi:10.1246/bcsj.71.619
(1998)

Article Doi