Inhibition of fucosyl transferase and fucosidase by a rigid bicyclic mimic of α-L-fucose

Article abstract of DOI:10.1016/S0040-4039(97)10473-7

A rigid bicyclic analogue of α-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for column chromatography, is a potent inhibitor of fucosidases and a weak inhibitor of a fucosyl transferase.