Stereoselective synthesis of polyoxamic acid from (R)-phenylglycine

Article abstract of DOI:10.1016/S0040-4039(97)10465-8

An efficient route for the synthesis of the biologically important amino acid, polyoxamic acid (1) has been developed via a syn selective Grignard reaction of vinylmagnesium bromide on (R)-N-Boc-phenylglycinal and utilization of the phenyl group as a masked carboxyl synthon.