Diethyl Ethoxymethylenemalonate in Triheterocycles: A New Synthesis of Pyrido[3,2-e]pyrimido[1,2-c]pyrimidines

Article abstract of DOI:10.1002/jhet.5570340627

Diethyl ethoxymethylenemalonate was used for the novel synthesis of the triheterocyclic 3-carbethoxy-9,11-disubstituted-4-oxo-4H-pyrido[3,2-e]pyrimido[1,2-c]pyrimidines from 4-aminopyrido[2,3-d]pyrim-idines via thermal cyclization of the intermediate ethy