Expeditious Semisynthesis of Docetaxel Using 2-Trichloromethyl-1,3-Oxazolidine as Side-Chain Protection

DOI: 10.1016/S0040-4039(00)76828-6

Source and publish data:

Tetrahedron Letters p. 3063 - 3064 (1994)

Update date:2022-08-03

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Authors:

Didier, Eric

Fouque, Elie

Commercon, Alain

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Article abstract of DOI:10.1016/S0040-4039(00)76828-6

Chloral reacts with phenylisoserine and N-Boc-phenylisoserine methyl esters to give N-unprotected 2-trichloromethyl-1,3-oxazolidines 4+4'.The corresponding oxazolidinecarboxylic acids 5+5' were esterified by 10-desacetyl-7,10-diTroc-baccatin III.Concomita

Full text of DOI:10.1016/S0040-4039(00)76828-6

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