ChemMedChem p. 1693 - 1696 (2017)
Update date:2022-08-05
Topics:
Monjas, Leticia
Swier, Lotteke J. Y. M.
Setyawati, Inda
Slotboom, Dirk J.
Hirsch, Anna K. H.
We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target.
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