Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries

Article abstract of DOI:10.1016/0040-4039(94)88498-6

A series of N-substituted DMT-hydroxymethylpyrrolidinol phosphoramidites has been prepared from trans-4-hydroxyproline. These can be coupled in high yield and purity using automated synthesis techniques, allowing a wide range of functionalities to be intr