Synthesis of N-substituted hydroxyprolinol phosphoramidites for the preparation of combinatorial libraries

DOI: 10.1016/0040-4039(94)88498-6

Source and publish data:

Tetrahedron Letters p. 9509 - 9512 (1994)

Update date:2022-08-03

Topics:

Authors:

Hebert, Normand

Davis, Peter W.

DeBaets, Elizabeth L.

Acevedo, Oscar L.

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Article abstract of DOI:10.1016/0040-4039(94)88498-6

A series of N-substituted DMT-hydroxymethylpyrrolidinol phosphoramidites has been prepared from trans-4-hydroxyproline. These can be coupled in high yield and purity using automated synthesis techniques, allowing a wide range of functionalities to be intr

Full text of DOI:10.1016/0040-4039(94)88498-6

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