Expeditious and stereoselective synthesis of chiral trans -β-hydroxy-δ-lactone systems

DOI: 10.1246/cl.1998.109

Source and publish data:

Chemistry Letters p. 109 - 110 (1998)

Update date:2022-08-03

Topics:

Authors:

Miyazawa, Masahiro

Matsuoka, Erika

Sasaki, Shinobu

Oonuma, Satoshi

Maruyama, Kimiyuki

Miyashita, Masaaki

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Article abstract of DOI:10.1246/cl.1998.109

Expeditious and stereoselective synthesis of chiral trans-β-hydroxy-δ-lactone systems starting from γ,δ-epoxy acrylates is described which involves the regioselective ring opening of an epoxide and the intramolecular conjugate addition of a hemiacetal alkoxide anion of δ-hydroxy-α,β-unsaturated esters as key steps.

Full text of DOI:10.1246/cl.1998.109

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