Expeditious and stereoselective synthesis of chiral trans -β-hydroxy-δ-lactone systems

Article abstract of DOI:10.1246/cl.1998.109

Expeditious and stereoselective synthesis of chiral trans-β-hydroxy-δ-lactone systems starting from γ,δ-epoxy acrylates is described which involves the regioselective ring opening of an epoxide and the intramolecular conjugate addition of a hemiacetal alkoxide anion of δ-hydroxy-α,β-unsaturated esters as key steps.