Bioorganic and Medicinal Chemistry Letters p. 1161 - 1166 (1999)
Update date:2022-08-02
Topics:
Petitou, Maurice
Driguez, Pierre-Alexandre
Duchaussoy, Philippe
Herault, Jean-Pascal
Lormeau, Jean-Claude
Herbert, Jean-Marc
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylareal hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.
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