Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

Article abstract of DOI:10.1016/S0960-894X(99)00156-0

A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylareal hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.