Synthesis of 4-guanidinopyrimidine nucleosides for triple helix-mediated guanine and cytosine recognition

DOI: 10.1016/S0040-4039(97)10627-X

Source and publish data:

Tetrahedron Letters p. 547 - 550 (1998)

Update date:2022-08-04

Topics:

Authors:

Doronina, Svetlana O.

Behr, Jean-Paul

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Article abstract of DOI:10.1016/S0040-4039(97)10627-X

Recognition of DNA sequences by triple helix-forming oligonucleotides is restricted to homopurine sequences. Based on geometrical considerations, a single nucleoside, 4-guanidinocytidine 1, was designed to recognize both guanosine (as the natural 1β anomer) and cytidine (as the 1α anomer) in a new triple helix context where the third strand is centered in the major groove of the target duplex. Several methods of synthesis of this nucleoside are described.

Full text of DOI:10.1016/S0040-4039(97)10627-X

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