Nucleosides and Nucleotides p. 1671 - 1679 (1998)
Update date:2022-08-03
Topics: Data Analysis
Efimov, Vladimir A.
Choob, Michael V.
Buryakova, Alla A.
Chakhmakhcheva, Oksana G.
The preparation of monomers for the synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been accomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono- PNA oligomers as well as chimeras consisting of phosphono-PNA and PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.
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(2009)Doi:10.1016/S0022-2860(00)00693-1
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(1999)Doi:10.1002/prac.19983400213
(1998)
