The Synthesis of 1,2,7,11b-Tetrahydroisoxazolobenzodiazepin-6(5H)-ones and 1,3,3a,9b-Tetrahydroisoxazoloquinolin-4(5H)-ones

Article abstract of DOI:10.1016/0040-4039(95)01523-X

The reaction of various ethyl 3-<<2-(1-hydroxyiminoalkyl)phenyl>carbamoyl>acrylates (2) with electron deficient olefins proceeds via a sequential dipole formation, dipolar cycloaddition sequence to furnish the tetrahydroisoxazolo<2,3-d><1,4>benzodiazepin-6(5H)-ones and tetrahydroisoxazolo<4,3-c>quinolin-4(5H)-ones (4) and (6).The product distribution reflects the nature of the reacting olefin and the position and extent of substitution on the acrylate moiety.