Tetrahedron Letters p. 1185 - 1188 (1998)
Update date:2022-07-29
Topics:
Tanaka, Katsunori
Kamatani, Mitsunobu
Mori, Hajime
Fujii, Shinobu
Ikeda, Kiyoshi
Hisada, Miki
Itagaki, Yasuhiro
Katsumura, Shigeo
3-(E)Methoxycarbonyl-2,4,6-trienal compound A was stereoselectively synthesized and found to show strong inhibitory activity toward phospholipase A2 (PLA2) from bovine pancreas. As the inhibitory mechanism of PLA2 by A, the irreversible formation of dihydropyridine resulting from the reaction of A with lysine residues in PLA2 is proposed based on the model reactions.
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(1968)
