Tetrahedron Letters p. 1107 - 1110 (1998)
Update date:2022-08-02
Topics:
Xu, Daqiang
Ciszewski, Lech
Li, Tangqing
Repic, Oljan
Blacklock, Thomas J.
Conditions are disclosed for the formation of either mono- or di-substituted ureas by reductive alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono- or di-substituted ureas in high yields.
View MoreContact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Suzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
LianYunGang Chiral Chemical(CHINA) CO.,LTD
Contact:+86-518-83616958 +86-519-82884848
Address:LianYunGang Chemical Industry Park (JiangSu)
Ningbo Inno Pharmchem Co., Ltd.
Contact:86-574-87319282
Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
Contact:86-21 60347964
Address:No.1304, West Meilong Road, Minhang District, Shanghai, China
Doi:10.1021/ic50005a039
(1963)Doi:10.1002/(SICI)1099-0682(199803)1998:3<375::AID-EJIC375>3.0.CO;2-9
(1998)Doi:10.1021/jacs.8b08100
(2018)Doi:10.1016/S0040-4020(02)00465-9
(2002)Doi:10.1021/jo00305a002
(1990)Doi:10.1007/BF02256980
(2000)
