Tetrahedron Letters p. 1107 - 1110 (1998)
Update date:2022-08-02
Topics:
Xu, Daqiang
Ciszewski, Lech
Li, Tangqing
Repic, Oljan
Blacklock, Thomas J.
Conditions are disclosed for the formation of either mono- or di-substituted ureas by reductive alkylation, which are readily adaptable to large scale preparations. Dehydrating agents such as acetyl chloride or trimethylsilyl chloride effectively promote the condensation of ureas and aldehydes. Reduction of the adducts affords the mono- or di-substituted ureas in high yields.
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