Practical methodology for the asymmetric synthesis of organofluorine compounds

Article abstract of DOI:10.1016/S0040-4039(98)00152-X

Pseudoephedrine α-fluoroacetamide (1), a nonvolatile, crystalline solid, is alkylated efficiently and with high diastereoselectivity with reactive alkyl halides. The alkylation products can be hydrolyzed under mild basic conditions to form α-fluoro carboxylates with high enantiomeric enrichment.