or purification steps. The crucial role of the residual amount
of water was revealed for the first time and it was shown that
the accuracy of the measurements can be greatly improved by
a simple modification of the experimental procedure (solvent
drying over molecular sieves and applying an excess of the
CDA or DCC). Using standard NMR spectrometers, a highly
efficient and environmentally benign procedure was developed
for fast analysis of the chiral samples (<5 min), which can be
suitable for routine usage for asymmetric synthesis and catalysis
applications. Successful measurements of as small as <10-5 g of
chiral sample were demonstrated.
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Acknowledgements
The research work was supported by Research Grant MK-
1434.2010.3 and RFBR grant 11-03-01055.
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