Journal of the Chemical Society. Perkin transactions I p. 2179 - 2185 (1996)
Update date:2022-08-03
Topics:
Morise, Xavier
Savignac, Philippe
Denis, Jean-Marc
Different approaches to the synthesis of 1-chloroalkylphosphinates are described. Initially, we tried to extend a reaction described by Kabachnik for the preparation of chloromethylphosphinic acid chlorides [R1(Cl)P(O)CH2Cl] to C-substituted derivatives. We also considered the possibility of synthesizing the title compounds by routes already described for the formation of diethyl 1-chloroalkylphosphonates. Although these methods have allowed us to obtain several of the desired phosphinates, they suffer from limitations that restrict their synthetic applications. Finally, we have developed a more general approach that allows the formation of a wide range of phosphinates. It involves a selective P-C bond formation by reaction of MeMgCl and PhMgCl with phosphonochloridates, which are prepared by P-chlorination of 1-chloroalkylphosphonates.
View MoreContact:+86-021-6989-5597
Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
Antaeus Bio-technology Co., LTD(expird)
Contact:021-31252569
Address:shanghai pudong
Contact:0510-85393305
Address:1619 Huishan Avenue, Huishan District, Wuxi,
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
website:http://www.sino-strong.com.cn
Contact:+86-28-82666753
Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)
Contact:+86-311-85208698 311-80837698
Address:NO.166, yuhua west road, SHIJIAZHUANG, China
Doi:10.1016/S0957-4166(98)00049-4
(1998)Doi:10.1021/jo972067j
(1998)Doi:10.1021/om970811k
(1998)Doi:10.1021/ja972768y
(1998)Doi:10.1021/jo01263a088
(1969)Doi:10.1002/(SICI)1099-1344(199804)41:4<273::AID-JLCR76>3.0.CO;2-1
(1998)
