2'-Deoxy-2'(S)-ethinyl oligonucleotides: A modification which selectively stabilizes oligoadenylate pairing to DNA complements

DOI: 10.1016/S0960-894X(98)00060-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 521 - 524 (1998)

Update date:2022-08-04

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Authors:

Buff, Rolf

Hunziker, Juerg

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Article abstract of DOI:10.1016/S0960-894X(98)00060-2

Oligonucleotides consisting of 2'-deoxy-2'(S)-ethinyl-thymidine, -uridine, and -adenosine have been prepared. Whereas the modified pyrimidine oligonucleotides uniformly lead to weaker pairing affinity with DNA and RNA complements, the corresponding adenine oligonucleotides show enhanced thermal stability in duplexes with complementary DNA and decreased stability with RNA.

Full text of DOI:10.1016/S0960-894X(98)00060-2

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