Lessons from the pseudorotational cycle: Conformationally rigid AZT carbocyclic nucleosides and their interaction with reverse transcriptase

Article abstract of DOI:10.1080/07328319808004726

Two conformationally locked carba-AZT nucleoside 5'-triphosphates built on a rigid bicyclo[3.1.0]hexane template showed exclusive Northern (₂E) and Southern (₃E) conformations, respectively. Inhibition of reverse transcriptase (RT) o

Full text of DOI:10.1080/07328319808004726

This article was downloaded by: [Nipissing University]
On: 04 October 2014, At: 23:47
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Lessons from the Pseudorotational Cycle:
Conformationally Rigid AZT Carbocyclic
Nucleosides and Their Interaction with
Reverse Transcriptase
Victor E. Marquez a , Abdallah Ezzitouni a , Pamela Russ a , Maqbool
A. Siddiqui a , Harry Ford Jr a , Ron J. Feldman b , Hiroaki Mitsuya b ,
Clifford George c & Joseph J. Barchi Jr a
a Laboratory of Medicinal Chemistry, Division of Basic Sciences ,
Washington, DC, 20375
b Experimental Retrovirology Section , Medicine Branch Division of
Clinical Sciences National Cancer Institute, National Institutes of
Health , Bethesda, MD, 20892
c Laboratory for the Structure of Matter , Naval Research Laboratory ,
Washington, DC, 20375
Published online: 22 Aug 2006.
To cite this article: Victor E. Marquez , Abdallah Ezzitouni , Pamela Russ , Maqbool A. Siddiqui ,
Harry Ford Jr , Ron J. Feldman , Hiroaki Mitsuya , Clifford George & Joseph J. Barchi Jr (1998)
Lessons from the Pseudorotational Cycle: Conformationally Rigid AZT Carbocyclic Nucleosides and
Their Interaction with Reverse Transcriptase, Nucleosides and Nucleotides, 17:9-11, 1881-1884, DOI:
10.1080/07328319808004726
To link to this article: http://dx.doi.org/10.1080/07328319808004726
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis, our
agents, and our licensors make no representations or warranties whatsoever as to the
accuracy, completeness, or suitability for any purpose of the Content. Any opinions and
views expressed in this publication are the opinions and views of the authors, and are
not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not
be relied upon and should be independently verified with primary sources of information.
Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands,
costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising
directly or indirectly in connection with, in relation to or arising out of the use of the
Content.

This article may be used for research, teaching, and private study purposes. Any substantial
or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply,
or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access
and use can be found at http://www.tandfonline.com/page/terms-and-conditions