Stereodivergent synthesis of all diastereomers of 4-aminoheptane-3,5- diol from (L)-serine

Article abstract of DOI:10.1016/S0040-4020(98)00232-4

The synthesis of the two diasteromeric meso forms of 4-amino-3,5- heptanediol (3R,4r,5S)-1a and (35,4s,5R)-1b and the two pseudo C₂-symmetric enantiomers (3S,5S)-1c and (3R,5R)-ent-1c is described by stereocontrolled ethylmagnesium bromide or d