Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-O,4'-C- methyleneribonucleosides

Article abstract of DOI:10.1016/S0040-4039(98)01084-3

Bicyclic nucleoside analogues with a fixed N-type conformation, 2'- O,4'-C-methyleneuridine and -cytidine, were incorporated into oligonucleotides, and the binding efficiency of the modified oligonucleotides to the complementary DNA and RNA as well as the