Synthesis of 4-[4′-bis(2″-chloroethyl)aminophenyl]-3,3,4,4-tetrafluorobutanoic acid [3,3,4,4-tetrafluorochlorambucil]

Article abstract of DOI:10.1016/S0022-1139(98)00127-4

Reaction of 2,2-dichloro-2-(4′-nitrophenyl)acetonitrile with mercury(II) oxide/pyridiniumpoly(hydrogen fluoride), (aqueous work-up), gave 2,2-difluoro-2-(4′-nitrophenyl)acetamide, from which were made the parent acid and thence its acid chloride. This and