Synthesis of 4-[4′-bis(2″-chloroethyl)aminophenyl]-3,3,4,4-tetrafluorobutanoic acid [3,3,4,4-tetrafluorochlorambucil]

DOI: 10.1016/S0022-1139(98)00127-4

Source and publish data:

Journal of Fluorine Chemistry p. 111 - 116 (1998)

Update date:2022-08-03

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Authors:

Buss, Christopher W.

Coe, Paul L.

Tatlow, John Colin

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Article abstract of DOI:10.1016/S0022-1139(98)00127-4

Reaction of 2,2-dichloro-2-(4′-nitrophenyl)acetonitrile with mercury(II) oxide/pyridiniumpoly(hydrogen fluoride), (aqueous work-up), gave 2,2-difluoro-2-(4′-nitrophenyl)acetamide, from which were made the parent acid and thence its acid chloride. This and

Full text of DOI:10.1016/S0022-1139(98)00127-4

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