Synthesis of new benzylic ethers of oximes derived from 1-phenyl- pyrazole compounds

Article abstract of DOI:10.1080/00397919808005973

In the scope of a research program aiming at the synthesis and pharmacological evaluation of new antithrombotic agents via rational molecular design, we describe in this paper the synthesis of benzyl ethers of aryl-pyrazolic oxime derivatives. Ethers' (2a-2c) and (3a-3c) are derived from 4-formyl-1-N-phenylpyrazole (4) in good yield. Designed as interphenylenic analogues of the ridogrel (1), one expects these compounds to present dual properties, i.e., thromboxane A₂ receptors antagonism and thromboxane synthetase inhibition.

Full text of DOI:10.1080/00397919808005973

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Synthesis of New Benzylic
Ethers of Oximes Derived from
1-Phenyl-pyrazole Compounds
Estela M. F. Muri b , Eliezer J. Barreiro a & Carlos A.
M. Fraga a
a Laboratório de Avaliação e Síntese de
Subst[acaron]ncias Bioativas (LASSBio), Faculdade
de Farmácia, Universidade Federal do Rio de
Janeiro, Rio de Janeiro, RJ, Brazil, CP 68006, ZIP
21944-910
b Instituto de Química, Universidade Federal do Rio
de Janeiro, Rio de Janeiro, RJ, Brazil
Version of record first published: 15 Aug 2006.
To cite this article: Estela M. F. Muri , Eliezer J. Barreiro & Carlos A. M. Fraga
(1998): Synthesis of New Benzylic Ethers of Oximes Derived from 1-Phenyl-pyrazole
Compounds, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 28:7, 1299-1321
To link to this article: http://dx.doi.org/10.1080/00397919808005973
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