Synthetic Communications p. 1299 - 1321 (1998)
Update date:2022-09-26
Topics:
Muri, Estela M. F.
Barreiro, Eliezer J.
Fraga, Carlos A. M.
In the scope of a research program aiming at the synthesis and pharmacological evaluation of new antithrombotic agents via rational molecular design, we describe in this paper the synthesis of benzyl ethers of aryl-pyrazolic oxime derivatives. Ethers' (2a-2c) and (3a-3c) are derived from 4-formyl-1-N-phenylpyrazole (4) in good yield. Designed as interphenylenic analogues of the ridogrel (1), one expects these compounds to present dual properties, i.e., thromboxane A2 receptors antagonism and thromboxane synthetase inhibition.
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