
Tetrahedron p. 4849 - 4858 (1998)
Update date:2022-09-26
Topics:
Fretz, Heinz
O-(Carboxydifluoromethyl)-L-tyrosine 1 was designed as a non phosphorous-containing phosphotyrosine isostere. A synthesis leading to the racemic as well as a stereoselective preparation of the L-configurated amino acid is described. Conversion into the respective Fmoc derivatives DL-2 and L-2 afforded building blocks suitably protected for solid-phase peptide synthesis.
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