Highly regioselective opening of optically active N-Boc-2,3-aziridino alcohol derivatives with metal halides

Article abstract of DOI:10.1016/S0040-4039(98)00204-4

Chiral 3-substituted N-Boc-2,3-aziridino alcohols are opened in a regio and stereoselective fashion by MgBr₂; the obtained 3-bromo derivatives can be reduced and deprotected under mild conditions to the corresponding 1,2- amino alcohols.