Chemical and Pharmaceutical Bulletin p. 587 - 590 (1998)
Update date:2022-09-26
Topics:
Satoh, Koji
Imura, Akihiro
Miyadera, Akihiko
Kanai, Kazuaki
Yukimoto, Yusuke
An efficient synthetic method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5- benzyl-4,7-dioxo-5-azaspiro[2,4]heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), which is a synthesis design system that generates suitable retrosynthetic routes from the standpoints of both novelty and practicality.
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