Tetrahedron Letters p. 3443 - 3446 (1998)
Update date:2022-08-03
Topics:
Hong, Joon H.
Lee, Kyeong
Choi, Yongseok
Chu, Chung K.
Enantiomeric synthesis of 3′-fluoro-apionucleosides was accomplished from 1,2-O-isopropylidene D-glyceraldehyde. The key intermediate, γ,δ-unsaturated tert-fluoro ethyl ester 7 from the fluoro allylic alcohol derivative 5 was achieved via Claisen rearrangement reaction with a 90.4% enantioselectivity. The condensation of the intermediate 10 with silylated N4-benzoylcytosine and 6-chloropurine followed by deprotection gave the desired pyrimidine and purine apionucleosides, respectively.
View MoreChengdu Biopurify Phytochemicals Ltd.
website:http://www.phytopurify.com
Contact:+86-28-82633397
Address:2F,No.11 Building,No.388 Rongtaidadao CNSTP,Wenjiang Zone,Chengdu,Sichuan, China
Chemtrade International ( China )
Contact:+86-532-86893005
Address:Rm 2-501, Huaxia Zonghe Building, No. 410 JInggangshan Road, Huangdao
SHANGHAI GILEADER ADVANCE MATERIAL TECHNOLOGY CO.,LTD
Contact:+86-021-58692556
Address:No.6 Building,No. 668 Hengan RD Pudong,Shanghai
Shanghai Rainbow Chemistry Co., Ltd.
Contact:+86-21-64968086-5815/5812
Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
Lianyungang Yunbo Chemical Co.,Ltd.
Contact:518-81066110
Address:B907,Dongsheng"Mingdu Square,21-2 East Chaoyang Road,Xinpu,(sale department)
Doi:10.1039/J19680002149
(1968)Doi:10.1016/S0040-4039(98)00570-X
(1998)Doi:10.1016/S0960-894X(98)00198-X
(1998)Doi:10.1039/j39680002898
(1968)Doi:10.1002/(SICI)1099-1344(199805)41:5<355::AID-JLCR88>3.0.CO;2-K
(1998)Doi:10.1080/00397911.2010.517366
(2011)