Oligoribonucleotides containing 8-oxo-7,8-dihydroguanosine and 8-oxo- 7,8-dihydro-2'-o-methylguanosine: Synthesis and base pairing properties

DOI: 10.1016/S0960-894X(98)00150-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 939 - 944 (1998)

Update date:2022-08-02

Topics:

Authors:

Kim, Sang Kook

Yokoyama, Shigeyuki

Takaku, Hiroshi

Moon, Byung Jo

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Article abstract of DOI:10.1016/S0960-894X(98)00150-4

7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2'-O-methylguanosine(8- oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8- oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8- oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized.

Full text of DOI:10.1016/S0960-894X(98)00150-4

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