Synthesis of two new maytansinoid model compounds from carbohydrate precursors

Article abstract of DOI:10.1080/07328309808002895

Maytansine (1) is a macrocyclic natural product with significant anti-cancer activity. A derivative (4) of D-glucal is converted to a model compound (10) for the lower periphery of the maytansinoid ring via alkylation at C-6 using an allylic sulfide anion

Full text of DOI:10.1080/07328309808002895

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Journal of Carbohydrate Chemistry
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Synthesis of Two New Maytansinoid
Model Compounds from Carbohydrate
Precursors
Thomas E. Goodwin a , Kimberley R. Cousins a , Heidi M. Crane a
,
Phyllis O. Eason a , Timothy E. Freyaldenhoven a , Charles C. Harmon
a , Brock K. King a , Christine D. LaRocca a , Robert L. Lile a , Shari
G. Orlicek a , Ronald W. Pelton a , Omer L. Shedd a , John S. Swanson
a & Joseph W. Thompson a
a Department of Chemistry , Hendrix College , Conway, Arkansas,
72032, USA
Published online: 15 Aug 2006.
To cite this article: Thomas E. Goodwin , Kimberley R. Cousins , Heidi M. Crane , Phyllis O. Eason ,
Timothy E. Freyaldenhoven , Charles C. Harmon , Brock K. King , Christine D. LaRocca , Robert L.
Lile , Shari G. Orlicek , Ronald W. Pelton , Omer L. Shedd , John S. Swanson & Joseph W. Thompson
(1998) Synthesis of Two New Maytansinoid Model Compounds from Carbohydrate Precursors, Journal of
Carbohydrate Chemistry, 17:3, 323-339, DOI: 10.1080/07328309808002895
To link to this article: http://dx.doi.org/10.1080/07328309808002895
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