A practical synthesis of free and protected guanidino acids from amino acids

Article abstract of DOI:10.1016/0040-4039(96)00299-7

Synthesis of protected guanidino acids in one pot reaction is achieved. Amino acids are treated with trimethylsilyl chloride, triethylamine, dicarbobenzoxy-S-methyl isothiourea in dichloromethane followed by removal of silyl group by treatment with methanol to give the corresponding carbobenzoxy guanidino acids.