European Journal of Medicinal Chemistry p. 181 - 187 (1998)
Update date:2022-07-30
Topics:
Domany, Gyoergy
Gizur, Tibor
Gere, Aniko
Takacs-Novak, Krisztina
Farsang, Gyoergy
Ferenczy, Gyoergy G.
Tarkanyi, Gabor
Demeter, Maria
A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe2+-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity.
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