1, 2-Disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors

Article abstract of DOI:10.1016/S0960-894X(98)00200-5

A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.