1, 2-Disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors

DOI: 10.1016/S0960-894X(98)00200-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1249 - 1254 (1998)

Update date:2022-08-02

Topics:

Authors:

Harmat, Nicholas J.S.

Di Bugno, Cristina

Criscuoli

Giorgi, Raffaello

Lippi, Annalisa

Martinelli, Adriano

Monti, Susanna

Subissi Subissi

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Article abstract of DOI:10.1016/S0960-894X(98)00200-5

A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.

Full text of DOI:10.1016/S0960-894X(98)00200-5

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