Bioorganic and Medicinal Chemistry Letters p. 1249 - 1254 (1998)
Update date:2022-08-02
Topics:
Harmat, Nicholas J.S.
Di Bugno, Cristina
Criscuoli
Giorgi, Raffaello
Lippi, Annalisa
Martinelli, Adriano
Monti, Susanna
Subissi
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
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(1968)Doi:10.1246/cl.1998.471
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(1931)Doi:10.1016/S0040-4039(98)00698-4
(1998)Doi:10.1021/jo9801059
(1998)
