Synthesis of 5-(β-D-ribofuranosyl)-pyridin-2-one: A 'deletion-modified' analogue of uridine

DOI: 10.1016/S0040-4039(97)00197-4

Source and publish data:

Tetrahedron Letters p. 1669 - 1672 (1997)

Update date:2022-08-04

Topics:

Authors:

Matulic-Adamic, Jasenka

Beigelman, Leonid

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Article abstract of DOI:10.1016/S0040-4039(97)00197-4

Pyridin-2-one C-nucleoside 2 was prepared using several different approaches. The most efficient pathway utilized the condensation of 2,3,5-tri-O-benzyl-D-ribono-1,4-lactone (4) and 2-(benzyloxy)-5-bromopyridine (5), followed by deoxygenation with Et₃SiH/BF₃·Et₂O and removal of the benzyl protecting groups.

Full text of DOI:10.1016/S0040-4039(97)00197-4

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