Inhibition of human cytomegalovirus protease N(o) with monocyclic β- lactams

Article abstract of DOI:10.1016/S0960-894X(98)00240-6

Monocyclic β-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N(o). Two series of these inhibitors are described, a peptidyl series of compounds and non- peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed.