Dimers of 5HT1 ligands preferentially bind to 5HT(1B/1D) receptor subtypes

DOI: 10.1016/S0960-894X(98)00222-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1407 - 1412 (1998)

Update date:2022-08-04

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Authors:

Perez, Michel

Jorand-Lebrun, Catherine

Pauwels, Petrus J.

Pallard, Isabelle

Halazy, Serge

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Article abstract of DOI:10.1016/S0960-894X(98)00222-4

New dimers of known 5HT₁ ligands (SHT, 1-NP or 8-OH-DPAT) have been prepared and evaluated at human cloned 5HT(1B), 5HT(1D) and 5HT(1A) receptors. Binding experiments show that all these dimers have better affinities at 5HT(1B/1D) receptors tha

Full text of DOI:10.1016/S0960-894X(98)00222-4

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