Tetrahedron Letters p. 4647 - 4650 (1998)
Update date:2022-08-05
Topics:
Hynes Jr., John
Overman, Larry E.
Nasser, Talal
Rucker, Paul V.
A concise route to the core of complex cardenolides is described. The sequence features use of a sulfone to join enantioenriched A and D ring fragments and also control intramolecular aldolization to generate ring C and an intramolecular Heck cyclization of an α-sulfenyl enol triflate to form the steroid skeleton.
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