Stabilization of Hoogsteen base pairing by introduction of NH2 group at the C8 position of adenine

DOI: 10.1016/S0040-4039(98)01026-0

Source and publish data:

Tetrahedron Letters p. 5221 - 5224 (1998)

Update date:2022-08-03

Topics:

Authors:

Kawai, Kiyohiko

Saito, Isao

Sugiyama, Hiroshi

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Article abstract of DOI:10.1016/S0040-4039(98)01026-0

The synthesis of 8-aminodeoxyadenosine containing oligonucleotides has been described. The incorporation of an amino group at the C8 position of adenine greatly stabilized the Hoogsteen base pairing in triplex formation.

Full text of DOI:10.1016/S0040-4039(98)01026-0

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